By Ricardo Azziz (auth.), Ricardo Azziz MD, MPH, MBA, John E. Nestler MD, Didier Dewailly MD (eds.)

The box of androgen extra issues has complicated considerably because the unique booklet of this ebook. The Androgen extra Society (AES) used to be based to assemble investigators within the box. a greater figuring out of the screening, development, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has more advantageous the medical care and diagnostic accuracy of those sufferers. New standards for the analysis of the polycystic ovary syndrome (PCOS) have been proposed in Rotterdam, standards that experience ended in controversy and, with a bit of luck, initiation of latest stories. The organization of insulin resistance with PCOS has been reinforced, and the position of metformin in tre- ing the infertility of the PCOS has been verified. hazards for diabetes and, extra cont- versially, heart problems in girls with PCOS have obtained big research. Our figuring out of the epidemiology and monetary impression of those issues has improved, emphasizing their severe significance. those are yet a couple of highlights of ways the terrain has replaced in a comparatively short time period. in accordance with those advances, the name of this e-book has been revised to mirror the starting to be significance of PCOS because the such a lot regular androgen extra illness in ladies, and arguably, because the one who may need the main critical antagonistic effects for common well-being. There are fewer chapters to supply a extra concentrated elucidation of the world. numerous chapters have been penned by means of new (and younger) authors who're carrying out state of the art examine within the field.

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Extra resources for Androgen Excess Disorders in Women: Polycystic Ovary Syndrome and Other Disorders

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Early in pregnancy, human chorionic gonadotropin stimulates these LH receptors, inducing progesterone synthesis by the corpus luteum during the first trimester. In contrast to the preovulatory follicle, the granulosalutein cells and the corpus luteum of pregnancy express large amounts of P450scc and 3E-HSD, permitting the synthesis of progesterone. 2. In the Adrenal The regulation of adrenal androgen production is poorly understood (35). The fetal adrenal produces large amounts of DHEAS, but these serve no essential role, because fetuses that cannot pro- Chapter 2 / Adrenal and Ovarian Steroidogenesis 29 Fig.

Reproduction 2004;128:379–386. 68. Voutilainen R, Miller WL. Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain cleavage enzyme, P450scc, in human steroidogenic tissues. Proc Natl Acad Sci USA 1987;84:1590–1594. 69. Insulin-like growth factor-I (IGF-I) may not be essential for ovarian follicular development: evidence from IGF-I deficiency. J Clin Endocrinol Metab 1992;74:539–542. 70. Welt CK, Smith ZA, Pauler DK, Hall JE. Differential regulation of inhibin A and inhibin B by luteinizing hormone, follicle-stimulating hormone, and stage of follicle development.

Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: Biological role in steroidogenic cell function. Endocr Rev 1993;14:222–240. 14. Chung B, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proc Natl Acad Sci USA 1986;83:8962–8966. 15. Yang X, Iwamoto K, Wang M, Artwohl J, Mason JI, Pang S. Inherited congenital adrenal hyperplasia in the rabbit is caused by a deletion in the gene encoding cytochrome P450 cholesterol side-chain cleavage enzyme.

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