By Jonathan A. Cotliar
This atlas offers trainees and working towards physicians a visible toolkit to aid realize and deal with this hard situation competently. this article highlights the medical variability of GVHD, and palms readers with the diagnostic clues to categorize sufferers in line with the present grading/staging instructions. additionally, this atlas bargains evidence-based diagnostic and remedy algorithms for physicians to exploit whereas at sufferers' bedsides.
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Additional resources for Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment
26. She K, Gilman AL, Aslanian S, Shimizu H, Krailo M, Chen Z, et al. Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease. Biol Blood Marrow Transpl. 2007;13(4):386–97. Distinct roles for donor- and host-derived antigen- A. Salhotra and R. Nakamura presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood. 2005;105(5):2227–34. Semin Immunol. 2006;18(5):276–83.
Arch Cancer Res. Ocular graft-versus-host disease: a review. Surv Ophthalmol. 2013;58:233–51. Chronic ocular graft versus host disease. In: Vogelsang GB, Pavletic SZ, editors. Chronic graft versus host disease: interdisciplinary management. New York: Cambridge University Press; 2009. 199–206. Chronic cicatrizing conjunctivitis. Curr Opin Ophthalmol. 2001;12:250–7. host disease with severe cicatrizing conjunctivitis mimicking cicatricial pemphigoid. Br J Dermatol. 2000;143:209–10. The role of medications in causing dry eye.
Ulcers may result from GVHD, viral infection, systemic medications or other causes. (a) Acute GVHD may present as mucositis involving any site on the oral mucosa (Photo courtesy of Robert Range, DDS). (b, c) Pseudomembranous ulcerations in chronic GVHD occur in many forms, and may eventually lose their pseudomembranous covering. Common sites include the base of the ventral tongue and the buccal mucosa. (d) Chronic GVHD may present on the cutaneous lip as wide, irregularly shaped ulcers in the setting of white lacy lesions, chapping, or generalized superficial hyperkeratosis of the cutaneous lip.