By Sidney Ochs (auth.), John S. Elam, Paul Cancalon (eds.)

Over the earlier a number of years, the velocity of analysis at the regulate of axonal progress has elevated at a awesome fee, and this job is mirrored in a growing to be literature facing a variety of elements of axonal progress and regener­ ation. it sounds as if well timed to check the position performed via axonal shipping within the intrinsic responses of neurons within the development and regrowth procedures. during the cooperation of the senior editors of this sequence, we now have been given the chance to convey this type of concentration to the present quantity. we want to recognize that the contributing authors attended a confer­ ence on "The position of Axonal delivery in Neuronal progress and Regenera­ tion" held in Tallahassee, Florida in March, 1983, backed by means of the Psycho­ biology examine middle of the Florida nation college. it's our desire that a few of the perceptions and insights expressed in those chapters resulted from our interactions.

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7:360-377. Lasek, R. , and Brady, S. , 1982, The structural hypothesis of axonal transport: Two classes FAST AXONAL TRANSPORT 29 of moving elements, in: Axop/asmic Transport (D. G. ), pp. 397-405, SpringerVeriag, Berlin, Heidelberg, New York. Lebeux, Y. , 1975, An ultrastructural study of the microfilaments in rat brain by heavy meromyosin labelling: The perikaryon, dendrites, and the axon, Cell Tissue Res. 160:1-36. ) and its possible role in excitability, J. Cell Bioi. 78:597-621. , 1982, Redistribution of proteins of fast axonal transport following administration of {1,{1-iminodiproprionitrile: A quantitative autoradiographic study, J.

Axotomy of frog spinal neurons at 15 C causes no signs of chromatolysis in cell bodies. , 1982). Also, in long-term cultures of rat sympathetic neurons, neurites will regenerate after a neuritotomy in the virtual absence of nonneuronal cells around the neurites and when nerve growth factor has been withdrawn from the cultures, which again suggests that the induction of regenerative response of the neuron is not mediated by the loss of an exogeneous trophic factor coming from the periphery (Campenot, 1981).

Brady, S. , and Lasek, R. , 1982, Axonal transport of membranous organelles in squid giant axons and axoplasm, J. Cell Bioi. 95:330a. , Padjen, A. , 1977, Axonal transport of organelles visualized by light microscopy: cinemicrographic and computer analysis, Brain Res. 136:197-213. Goldberg, D. , Harris, D. , Lubit, B. , and Schwartz, J. , 1980, Analysis of the mechanism of fast axonal transport by intracellular injection of potentially inhibitory macromolecules: Evidence for a possible role of actin filaments, Proc.

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