By Wilhelm, Klaus-Peter

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Extra resources for Bioengineering of the Skin: Skin Imaging & Analysis

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In VD, modern digital image acquisition techniques are used for quantitative and automated image analysis and long-term observations of the progression of skin tumors. In ELM, a glass plate is placed on the skin surface, a contact fluid is inserted between the plate and the skin, and the surface images are digitized like in VD. With this method, the penetration of light into the uppermost skin layers is improved, and the images contain more information. The advantage of VD and ELM is that the skin is imaged under standardized and reproducible conditions concerning illumination and calibrated imaging of colors.

The light, which is reflected at a mirror in the reference arm and backscattered at optical inhomogeneities inside the skin from the measurement arm, is superimposed at a photodiode (PD) and detected. Because the light source is broadband and low coherent, a measurement signal at the PD output is only obtained if the optical path lengths in both the arms are equal. A scanning over depth is achieved by changing one of the optical path lengths, what can be achieved by moving the mirror or the lens system.

To us, the most likely seems the theory of Schellander and Headington that ‘‘the creases and indentations found in the resting skin act as prefolds which determine the exact points of flexion and extension when the stratum corneum is deformed’’ (23). In short, they are pleats that allow deformations compensating for stresses, which could result in cracks. , elbow, knee, and dorsum of fingers; Fig. 6A and B). The cobblestone appearance found in these regions provides an additional reserve for stretching.

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