By P. M. D. Foster (auth.), Philip L. Chambers, Claire M. Chambers, Helmut Greim (eds.)

This complement comprises the papers submitted at EUROTOX 88, the joint Congress of the eu Society of Toxicology and the Federation of the eu Societies of Toxicology. The subject matter was once one in every of tracking and studying the consequences of poisonous elements within the organic reaction on the subcellular point. Mechanisms of steel carcinogenicity are mentioned in addition to the biomonitoring of chemical publicity. stories are supplied at the position of person variations in guy and the influence of chance evaluation. Papers seem facing the genetic keep an eye on of drug metabolizing enzymes. The function of metabolism in natural particular toxicity is mentioned. details is integrated at the toxicological impression of chemical substances interfering with the endocrine procedure in addition to at the results of toxicants at the immune approach. displays take care of the present prestige of possibility review in environmental toxicology.

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Extra info for Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances: Proceedings of the European Society of Toxicology Meeting held in Munich, September 4–7, 1988

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As assessed by testing paired sampies from 18 individuals, lung parenchyma was significantly more efficient than bronchial tree in decreasing Cr(VI) mutagenicity, and also contained considerably higher concentrations of GSH (Petruzzelli et al 1989). 34 s. De Flora et al. Interindividual variations in Cr(VI) reduction As assessed by comparatively testing homogeneous series of tissue sampies for their ability to decrease the mutagenicity of Cr(VI), it was possible to determine the extent of interindividual variations in chromium metabolism.

In New Caledonia, mining and refining industry in which the airbone concentrati on of nickel subsulphide has always been negligible, no excess incidence of lung or upper respiratory tract cancer has been found (Goldberg et al 1987). So far no excess carcinogenic risk has been demonstrated beyond doubt in users of nickel compounds or alloys (Grandjean et al 1988). Of interest is that in refineries where good hygiene practiee has been implemented, the risk of the development of nasal sinus or lung cancer has disappeared.

Such findings suggest that control of chromatin structure and gene transcriptional activity could be affected by low concentrations of Ni + + in cell nuclei, possibly contributing to nickel carcinogenesis. Nickel Carcinogenesis 43 Infidelity of DNA Synthesis and Depurination of DNA Zakour et al (1981) reviewed the evidence that 'carcinogenic' metals impair the fidelity of DNA replication in vitra; they proposed three hypotheses to explain this phenomenon: a) alte red substrate conformation at the substrate-binding site of DNA polymerase, b) altered enzyme conformation at the catalytic site of DNA polymerase, or c) altered template-base specificity, owing to reactions of metals with DNA that affect the complementarity of base-pairing.

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