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Extra info for Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and their Analogs. The Peptides Analysis, Synthesis, Biology, Vol. 8
Karger, Basel, Switzerland. 95. , Kleeman, C , and Vorherr, Η. (1980). Water metabolism and the neu rohypophysial hormones. In "Metabolic Control and D i s e a s e " (P. K. Bondy and L. E. ), pp. 1241-1323. W. B. Saunders, Philadelphia. 96. White, W. , and Bergland, R. Μ. (1972). Experimental inappropriate ADH secretion caused by positive-pressure respirators. J. Neurosurg. 36, 6 0 8 - 6 1 3 . 97. Wiegand, S. , and Price, J. L. (1980). Cells of origin of the afferent fibers to the median emimence in the rat.
1972). Experimental inappropriate ADH secretion caused by positive-pressure respirators. J. Neurosurg. 36, 6 0 8 - 6 1 3 . 97. Wiegand, S. , and Price, J. L. (1980). Cells of origin of the afferent fibers to the median emimence in the rat. J. Comp. Neurol. 192, 1-19. 98. Zerbe, R. L . , Baylis, P. , and Robertson, G. L. (1981). Vasopressin function in clinical disorders of water balance. In " T h e Pituitary" (C. Beardwell and G. L. ), pp. 2 9 7 - 3 2 9 . Butterworth, London. 99. Zerbe, R. , and Robertson, G.
The oxytocin gene predicts an extra basic amino acid (His or Arg) following immediately after the known neurophysin sequence. This basic amino acid corresponds precisely with the cleavage signal separating the neurophysin and glycopeptide in the vasopressin precursor. Whether the ancestral oxytocin gene also possessed a C-terminal peptide and whether this part was discarded following gene duplication, leaving the terminal basic amino acid in this precursor as a rudiment of the ancestral cleavage signal, remains speculation.