By G.E.W. Wolstenholme; & Maeve O'Connor (Editors)
Chapter 1 Chairman's beginning comments (pages 1–3): M. G. P. Stoker
Chapter 2 mobile occasions previous Interferon Formation (pages 4–17): D. C. Burke, J. J. Skehel, A. J. Hay and Shan Walters
Chapter three The Systemic Induction of Interferon (pages 19–38): Monto Ho, Bosko Postic and Yang H. Ke
Chapter four Statolon, as an Inducer of Interferon (pages 39–49): W. J. Kleinschmidt and L. F. Ellis
Chapter five Interferon Induction in Mouse and guy with Viral and Non?Viral Stimuli (pages 50–63): Thomas C. Merigan
Chapter 6 an easy method for the Mass creation of Human Interferon: The Human Amniotic Membrane (pages 64–77): Charles Chany, Francoise Fournier and Ernesto Falcoff
Chapter 7 Purification of Interferons (pages 78–94): okay. H. Fantes
Chapter eight at the obvious Heterogeneity of Rabbit Interferons (pages 95–109): Robert R. Wagner and Thomas J. Smith
Chapter nine experiences at the Mechanism of motion of Interferon (pages 110–127): Wolfgang okay. Joklik
Chapter 10 The Mode of motion of Interferon (pages 128–142): P. De Somer and C. Cocito
Chapter eleven experiences on Interferon motion (pages 143–159): J. A. Sonnabend, E. M. Martin and E. Mecs
Chapter 12 The Mechanism of motion of Interferon (pages 160–185): Hilton B. Levy and William A. Carter
Chapter thirteen a few Determinants of the Interferon?Induced Antiviral kingdom (pages 186–203): S. Baron, C. E. Buckler and F. Dianzani
Chapter 14 Of Mice and males: reviews with Interferon (pages 204–217): N. B. Finter
Chapter 15 impact of alternative Carcinogenic brokers at the creation of Interferon in Tissue tradition and within the Animal (pages 218–239): Edward De Maeyer and Jaqueline De Maeyer?Guignard
Chapter sixteen The impact of Interferon arrangements on good friend Leukaemia in Mice (pages 240–261): I. Gresser, J. Coppey, D. Fontaine?Brouty?Boye, E. Falcoff, R. Falcoff, F. Zajdela, C. Bourali and M. T. Thomas
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Additional info for Ciba Foundation Symposium - Interferon
C. : PAHO/WHO Scientific Publication 147. , and POSTIC, B. (19676). , 214, 123-1231. KE, Y. , and MEXICAN, T. C. (1966). Nufirre, Lord, 211, 541-542. KE, Y. , SINGER, S. , and Ho, M. (1966). Proc. SOC. cxp. Biof. , 121, I 81-1 83. KONO,Y. (1967). Proc. Soc. exp. Biol. , 124, 155-160. , and Ho, M. (1965). Virofogy,25, 162-166. , and BRAUN, W. ) (1964). BacteriulEiidotoxiru. : Quinn & Boden Co. L u m , M. B. (1960). Atin. Acud. ,88, 83-98. , and KANASHIRO, R. S. (1966). ]up. J. esp. M d . , 36,481-487.
Recently we pcrformed some on the rate of disappearance of interferon, its distribution in tissues, and its renal excretion. Interferon disappears very rapidly after it is inoculated in the blood stream. Therefore, large amounts must be administered initially in order to study the kinetics of its disappearance. This agrees well with calculations based on the data of Baron and co-workers (1966), and Gresser and co-workers (1967) for the mouse. Where does the interferon go t o ? Some of it is excreted, but proportionately not very much (see below).
FURTHER PURIFICATION OP STATOLON The procedure for isolating statolon from the fermentation filtrate has consisted essentially of precipitation with a water-miscible organic 42 W . J. K L E I N S C H M I D T A N D L . F. E L L I S solvent. In early attempts to identify the active molecule of such statolon preparations, our evidence indicated that the antiviral activity was associated with a polysaccharide fraction (Kleinschmidt and Probst, 1962). Statolon, however, admittedly was not pure and because of this there was, of course, uncertainty as to its identity.