By Odile Enjolras

Hemangiomas and superficial vascular malformations are disfiguring birthmarks which could take place over sixty five% of a kid's physique. This atlas will concentrate on the class, multidisciplinary procedure, reputation and id, and therapies for this category of pathology. Vascular malformations, composed of malformed vessels, by no means regress and occasionally extend quickly. They take place in any physique half together with viscera. They reason beauty difficulties, useful incapacity and will be existence threatening and require radiologic imaging and pathology to acknowledge and practice differential analysis on a variety of vascular anomalies. moreover, new thoughts, together with molecular biology tactics, have advanced permitting much less invasive and a more desirable method of analysis and therapy.

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Sample text

The IH regressed relatively rapidly; however, when the girl was 4 years old the area was left with altered, yellowish skin (anetoderma) (b). 39 INFANTILE HEMANGIOMA (IH) Clinical Aspects, Investigations, and Treatment Multiple small painful ulcers arose on this large and thick IH of the hand and forearm during its proliferating phase. It was demonstrated that nerves are most numerous in growing hemangiomas (59): one can hypothesize that these nerves may contribute to the sharp pain suffered by the infant when an ulcerated hemangioma is exposed to air or physical contact.

If performed, GLUT1 staining is indispensable (100% þ in IH). US ¼ ultrasonography; AVM ¼ arteriovenous malformation; CT ¼ computed tomography; MRI ¼ magnetic resonance imaging; GLUT1 ¼ glucose transporter 1; IH ¼ infantile hemangioma. 24 INFANTILE HEMANGIOMA (IH) positive in 100% of IH endothelial cells and negative in the other infantile vascular tumors, including congenital hemangiomas, tufted angioma, and kaposiform hemangioendothelioma. Treatment We must first emphasize the fact that a majority of IH are small lesions, often located in areas covered by clothes, and are left to spontaneously disappear.

She had been on steroid treatment for 2 weeks (prednisolone 2 mg/kg daily); the dosage was increased to 3 mg/kg daily, without improving her breathing. Brain MRI and hepatic ultrasonography were normal. Laryngotracheal endoscopy (courtesy of Dr. G. Roger, Division of ENT Surgery, Hoˆpital Armand Trousseau, Paris, France) demonstrated major pharyngo- and laryngotracheal involvement with significant subglottic stenosis (60% estimated) and extension to the right lateral wall of trachea down to the carina (a, b).

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