By T. L. Diepgen, P. J. Coenraads (auth.), Prof. Lasse Kanerva M.D., Ph.D., Prof. Dr. med. Peter Elsner, Prof. Jan E. Wahlberg M.D., Ph.D., Prof. Howard I. Maibach M.D. (eds.)

Due to adjustments in sleek lifestyles, occupational dermatoses are expanding. This thoroughly revised and accomplished variation presents the concise info wanted in facing sufferers within the box of occupational dermatology. It combines a hugely sensible method of occupational dermatology with the talents and examine event of experts in medical and experimental dermatology. The spectrum of illnesses coated during this e-book contains: allergic and irritant dermatitis; touch urticaria; photodermatoses; infectious illnesses; pores and skin tumors; systematic reactions as a result of percutaneous absorption; predisposed illnesses and occupational pores and skin difficulties. the data urgently wanted for day-by-day sufferer administration is equipped as fast reference via concise tables, algorithms, and figures on the best way to optimise the diagnostic approaches for top quality care. This ebook will turn out of serious curiosity to all who're enthusiastic about treating sufferers with occupational epidermis illnesses.

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1. Correlation between ceramide 3 (CER3) levels and trans epidermal water loss (TEWL) values in 47 subjects with atopic dermatitis. 31 Evaluation of Barrier Function and Skin Reactivity in Occupational Dermatoses 39 1 levels (Di Nardo et al. 1996 a). The same authors employed a 24-h application of xylene and toluene to induce acute irritation (Di Nardo et al. 1996b). On comparing values of the different classes of lipids with clinical irritation parameters, a negative correlation was obtained. Based on clinical observations, two populations were selected: less reactive and hyper-reactive, which also differed in the total weight of lipids, ceramides and triglycerides.

J Pediatr 91:998-1000 Goffinet M (1977) Clinically presumptive toxicity of various ear-drops (in French). Acta Otorhinolaryngol Belg 31:585-590 Goluboff N, MacFadyen D (1955) Methemoglobinemia in an infant. J Pediatr 47:222 Greaves SJ, Ferry DG, McQueen EG, et al (1975) Serial hexachlorophene blood levels in the premature infant: dinical pharmacology of hexachlorophene in newborn infants. NZ Med J 81:334-336 Haddad L (1990a) Miscellany. In: Haddad L, Winchester J (eds) Clinical management of poisoning and drug overdose.

Site of Application Regional differenees in permeability of skin largely depend on the thickness of the intaet stratum eorneum (Wester and Maibaeh 1989). Age The greatest toxicological response to topical administration has been seen in the infant. The preterm infant does not have intaet barrier funetion and henee is more suseeptible to systemic toxicity from topically applied drugs (Greaves et al. 1975). Anormal fuIl-term infant probably has a fully developed stratum eorneum with eomplete barrier funetion (Rasmussen 1979).

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