By Neil S. Sadick, Mary Lupo, Diane S. Berson, Zoe Diana Draelos

Cosmeceuticals are skin-care items that fall among a beauty and a pharmaceutical; that's, they've got energetic constituents that counter epidermis getting older and advertise epidermis rejuvenation. As such, they're a useful adjunct to the beauty dermatologist or plastic general practitioner appearing minimally invasive aesthetic systems. lots of those items were constructed in Europe and are just now being brought to the united states, so this advisor from professional practitioners explains how top to combine the potential for cosmeceutical items into the simplest foreign medical perform.

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Extra resources for Cosmeceutical Science in Clinical Practice (Series in Cosmetic and Laser Therapy)

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15. Gottscha TE, Bailey JE, Cosmetic, Toiletry and Fragrance Association. In: Gottscha TE, Bailey JE, eds. International Cosmetic Ingredient Dictionary and Handbook. Washington, DC: CFTA, 2008: 1170–4. 16. Mehta RC, Smith SR, Grove GL, et al. Reduction in facial photodamage by a topical growth factor product. J Drugs Dermatol 2008; 7: 864–71. 17. Draelos ZD. Exploring the pitfalls in clinical cosmeceutical research. Cosmet Dermatol 2007; 20: 556–8. 18. Gold MH, Goldman MP, Biron J. Human growth factor and cytokine skin cream for facial skin rejuvenation as assessed by 3D in vivo optical skin imaging.

Once the information is received, dermatologists can provide greater individualized patient skin care. PEPTIDES: WHAT IS TO COME? To further explore the power of peptides for anti-aging applications, Procter and Gamble Beauty Science continues diligent research on the matter. Osborne et al. (29) indicated how human skin equivalents provide useful in vitro models to identify and evaluate cosmetic technologies based on knowledge gained via gene expression profiling of aged skin. A series of acyl-modified di-, tri-, and tetra-peptides were synthesized and screen in vitro for their capacity to stimulate production of collagen-I as well as other skin structural proteins, including procollagen-C, collagens III, IV, and VI, elastin, fibronectin, CD44, vimentin and laninins I and IV in both dermal fibroblasts and human skin equivalent cultures.

As such it could function in collagen remodeling (15, p. 2257). Experiments using GHK–Cu have demonstrated stimulation of both type I collagen and the GAG’s dermatan sulfate and chondroitin sulfate in rat wounds as well as cultured rat fibroblasts (16, p. 962). Human fibroblast cultures showed increased synthesis of dermatan sulfate and heparin sulfate after addition of the tripeptide–copper complex (18, p. 1049). Limited clinical trials with patients using a facial cosmeceutical product containing the complex as the active ingredient did demonstrate improvement in the appearance of fine lines as well as increase skin density and thickness (19).

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