By Professor Dr. Günter Burg, Professor Dr. Dr. h.c. Otto Braun-Falco (auth.)

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Large euchromatic nuc1eus and prominent nuc1eoli (N), one of which is situated near the nuc1ear membrane. The cytoplasm contains numerous ribosomes and same mitochondria (m). 5 Immunoblasts The term" immunoblast " was coined by Dameshek [176] to describe precursors of plasma cells. Later, the term was also applied to bl asts derived from T-Iymphocytes. Immunoblasts develop from smalI, normallymphocytes upon appropriate stimuli. This can be shown in vitro by phytomitogens. Phytohemagglutinin stimulates predominantly T -lymphocytes, whereas pokeweed mitogen acts predominantly on B cells.

Centroblastic lymphoma, diffuse or follicular 2. Follicular lymphoma, centroblastic/centrocytic type (Brill-Symmer's disease) 3. Nodular and diffuse variants of histiocytic [570] or large lymphoid cell [193] malignant lymphoma 4. "Polymorphous" variant of" immunocytoma" [426] C> Above left: Part of a large follic1e with zonal arrangement of the cells. Giemsa, x 380 C> Above right, below left and right: Variants of medium-sized and large nonc1eaved cells of follic1e centers, some of which resemble immunoblasts (compare with figures on p.

Some cells show deep nuclear indentations, some have lysosome-like granules (---+). Courtesy of B. Mahn, MD, Institute of Pathology, University of Essen, FRG. x 5,600 C> Below: With higher magnification one sees a deep nuclear indentation and, near the nuclear membrane, a nucleolus. The heterochromatin is uniformly distributed, but with peripher al condensation. The cytoplasm contains well-developed ribosomes, but only short strands of endoplasmic reticulum. The few mitochondria are mostly situated opposite the nuclear pocket.

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