By R. Numerof, Charles A. Dinarello, Khusru Asadullah

Cytokines and cytokine receptors stay a space of serious curiosity for the advance of unique treatments for cutaneous inflammatory ailments. Anti-TNF therapeutics have confirmed to be powerful within the remedy of psoriasis, and scientific investigations have now all started for different cytokine-directed treatments, reminiscent of these focusing on IFN-g, IL-12p40, and IL-18. as well as therapeutics that focus on cytokines without delay, techniques that concentrate on cytokine signaling pathways are in improvement. This ebook summarizes the findings of the 56th foreign Workshop of the Ernst Schering study origin that interested by "Cytokines as power healing ambitions for Inflammatory pores and skin Diseases".

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1987), rheumatoid arthritis (Seitz et al. 1988), psoriasis (Fierlbeck et al. 1990), and others. IFN-α can also induce underlying autoimmune 16 B. Skurkovich, S. Skurkovich diseases, including autoimmune thyroid disease (Murakami et al. 1999), type I diabetes (Fabris et al. 1998), and rheumatoid arthritis (Pittau et al. 1997). In multiple sclerosis, evidence points to IFN-γ as having a direct role in inducing central nervous system demyelination (Horwitz et al. 1997). IFN-γ in chronic high levels may set in motion the autoimmune process.

IX International Congress of Dermatology, Abstract Book, Beijing, p. 289 Smoller BR, McNutt NS, Gray MH, Krueger J, Hsu A, Gottlieb AB (1990) Detection of the interferon-gamma-induced protein 10 in psoriasiform dermatitis of acquired immunodeficiency syndrome. Arch Dermatol 126:1457– 1461 Snapper CM (1996) Interferon-gamma. In Snapper CM (ed) Cytokine regulation of humoral immunity. Basic and clinical aspects. John Wiley & Sons, New York, p. 325 Snider LA and Swedo SE (2003) Post-streptococcal autoimmune disorders of the central nervous system.

30 31 31 33 35 37 39 40 Abstract. Targeting TNFα provided proof of concept for the role of proinflammatory cytokines in promoting cutaneous inflammation, particularly psoriasis. Recent studies have elucidated the presence of numerous cytokine and chemokine activities in psoriatic skin and synovium. There is considerable interest in the potential of such activities as novel therapeutic targets. IL-15 is an innate response cytokine that activates leukocyte subsets via binding to its unique IL-15Rα and shared β and γ chain receptors.

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