By Klaus Peter Wilhelm, Hongbo Zhai, Howard I. Maibach

The foundational reference in dermal toxicology, this vintage textual content has been thoroughly revised to deliver it brand new within the new 8th version, with nearly a 3rd of its chapters being newly extra. The constitution of the textual content has additionally been reorganized to permit more uncomplicated place of a subject matter of curiosity. With contributions from major foreign specialists, this maintains the culture of supplying unsurpassed theoretical and sensible tips for all these engaged on examine elements, on functional scientific matters, and at the regulatory facets of publicity to poisonous substances.

This new version comprises updates to every bankruptcy and contributions from best foreign specialists, presents an in-depth precis of analysis and regulatory functions on the topic of dermal toxicology and pharmacology, offers many new chapters that describe the most recent advances in dermatotoxicology, and addresses quite a few degrees of workmanship concerning the improvement and use of dermal publicity facts. New chapters contain these on safety terminology, pharmacogenetics and dermatology, ethnic changes in pores and skin homes, and the foundations and perform of percutaneous absorption.

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2, are being developed. The initial event is the bioavailability of a compound. It determines if further assessment is required. If bioavailability is negligible, the hazard and risk assessment can be concluded. Bioavailability is directly linked to physicochemical properties, such as the molecular weight or the octanol–water partition coefficient. Furthermore, it depends on exposure determinants, such as duration and concentration. 2 Data informing hazard and risk assessment of human skin sensitization.

Artificial skin substitutes are also available to study the effects of harmful or dangerous agents. In essence, the skin has everything: from stem cells, signaling, and cellular differentiation, to inflammation, diseases, and cancer. All these facets could become excellent models to further study hormesis and its clinical implications following exposure to a variety of toxic compounds and pharmaceutic agents. REFERENCES 1. Calabrese EJ, Baldwin LA. The frequency of U-shaped dose– responses in the toxicological literature.

Gibelli N, Zibera C, Butti G, et al. Hormonal modulation of brain tumor growth: a cell culture study. Acta Neurochir (Wien) 1989; 101: 129–33. 34. Kawamura A, Tamaki M, Kokunai T. Effect of dexamethasone on cell proliferation of neuroepithelial tumor cell lines. Neurol Med Chir (Tokyo) 1998; 38: 633–40. 35. Paoletti P, Butti G, Zibera C, et al. Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors. J Neurosurg 1990; 73: 736–42. 36. Bentel JM, Lebwohl DE, Cullen KJ, et al.

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