By S. W. Jacob (auth.), S. W. Jacob M.D., R. J. Herschler B. S., Dr. H. Schmellenkamp (eds.)

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Extra info for DMSO: Die Anwendung in der Medizin The Use of DMSO in Medicine

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Der prozentuale Anteil von freier oder durch Esterspaltung gebildeter Arachidonsaure wurdefUr jedes Experiment in Dreifachbestimmung berechnet (Tabelle 2). Diese Daten deuten darauf hin, daB DMSO in vitro keine signifikante Wirkung auf eine Rohpraparation von Schweinepankreas -PLAz aufweist. TabeUe 2. Wirksamkeit von DMSO auf die Aktivitiit der PLAz (in vitro) Zusatz DMSO [%1 Freie Arachidonsiiure [%1 0,0 78 ~ 1~ ~ ~ 5~ 10,0 79 68 Phannakologie und Toxikologie von Dimethylsulfoxid (DMSO) IXXXlill18illi8' XXD1a1aaali IBM ~ phoIphoIlpidi Inhibited by J Stimulus - - ..

Nature 237: 452 White RH (1982) Analysis of dimethyl sulfonium compounds in marine algae. J Marine Res 40 (2): 529-535 Pharmakologie und Toxikologie von Dimethylsulfoxid (DMSO) B. CALESNICK und A. DINAN ExperimenteUer Teil DMSO wurde friiher als Losungsmittel in chemischen Laboratorien, als Frostschutzmittel, Hydraulikfliissigkeit und als Farben- und Lackentfemer in der Industrie eingesetzt. Schon urn 1960 begann sich die Aufmerksamkeit auf den therapeutischen Einsatz bei Muskelschmerzen, Verstauchungen, Neuralgien und GefaBerkrankungen zu richten (dela Torre 1983).

Welches ist nun die minimale Anzahl an DMSO-Molekiilen, die eine Wirkung auf die Viskositiit von Hyaluronsiiure hat, freie Radikale, wie Hydroxylradikale, unschiidlich macht, sich mit Wasser assoziiert, urn die Eiskristallbildung in Geweben bei tiefen Temperaturen zu vermeiden, oder sonst irgendwelche pharmakologischen Eigenschaften zeigt? Wir wissen es nicht. Die unbeabsichtigte Anwendung von DMSO (oder MSM) als Nahrungsbestandteil ist alt; die bewuBte Anwendung von DMSO als Nahrungsbestandteil oder als pharmakologisch wirksame Substanz ist neu, und der Unterschied ist abhiingig von der angewandten Konzentration, der Applikationsform und der Art der Aufnahme.

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