By Edward M. Scolnick (Eds.)

Thoughts to lessen scientific uncertainty and construct proof became serious to the development of scientific wisdom and smooth clinical perform. As new options and methods have arisen, so has the necessity for a present reference paintings. Drug Discovery and layout examines the newest examine within the improvement of those new concepts. a few of the issues coated contain angiotensin changing enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal brokers.

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Reviews by Soubrier et al. (59) and Corvol et al. (60, 61) summarize much of the recent progress. ANGIOTENSIN-CONVERTING ENZYME INHIBITORS 19 Angiotensin-converting enzyme is found in mammalian tissue in two forms, the somatic enzyme and a testicular (germinal) enzyme with molecular weights in the range 150,000–180,000 and 90,000–110,000, respectively. When the somatic enzyme was cloned, the presence of two homologous domains each containing the same Zn2+ binding sequence was apparent (62, 63).

As expected in both models of hypertension, the addition of diuretics enhanced the antihypertensive activity of captopril (105). D. Metabolism and Pharmacokinetics [35S]- and [14C]-captopril have indicated complex and Studies with extensive metabolism. The disulfide dimer of captopril is observed, as well as mixed disulfides with cysteine, N-acetylcysteine, and glutathione. There is covalent reversible binding to plasma proteins, which is similarly considered to involve disulfide linkages. S-Methylcaptopril and its sulfoxide are also formed (105).

Thus, when interventions are made in it, the results are often difficult to interpret in a definitive 38 JOEL MENARD AND ARTHUR A. PATCHETT FIG. 2. Additional ACE inhibitors available in the United States way, and this problem is well exemplified in studies comparing saralasin and teprotide (180). Teprotide was more effective than saralasin in lowering blood pressure in low-renin hypertensive patients; this was interpreted as evidence of agonistic properties of saralasin. It could also be due to the bradykinin accumulation induced by the ACE inhibitor teprotide, in addition to its interruption of angiotensin II generation (181).

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