By Peter J. Bentley

Written essentially for college students of drugs, pharmacy, and pharmacology, this introductory ebook presents a concise precis of the foundations that underlie the technology of pharmacology. It offers the fundamental strategies required for realizing the use, mechanisms of motion, toxicity and uncomfortable side effects, and healing software of gear in guy. hence the ebook can also be of curiosity to scientific practitioners and to organic and clinical scientists. between subject matters coated are the assets of gear, the way in which they're administered and handled within the physique, in addition to innovations concerning the nature in their activities. The final comprise their chemical interactions with parts of cells and the style during which those bring about therapeutically fascinating in addition to bad or even poisonous results. additionally, clinically similar matters, similar to drug interactions, teratogenic and carcinogenic results are mentioned. the improvement and checking out of latest medicinal drugs also are defined. for simple reference, in the back of the publication there's a word list of gear named within the textual content.

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Additional info for Elements of Pharmacology: A Primer on Drug Action

Sample text

The ability of enzymes to change the structure of certain drugs and so activate them may also be utilized to prolong their action, as is seen in the preparation of peptides with 6. Drug absorption, distribution, and elimination 31 additional, protective, terminal chains of amino acids, and in the esterification of steroids. Such compounds can often persist in inactive form for relatively long periods of time in the body, but as a result of their metabolism, they are slowly changed to their active form.

These changes usually result in a reduction or abolition of its actions (inactivation) and an increase in its water solubility, which facilitates its excretion in the urine and bile. There are, however, a number of occasions when the effectiveness of drugs is enhanced as a result of their metabolism so that an activation is said to occur. In other instances, metabolites may retain an appreciable amount of the original activity, or they may have other effects, including toxic actions. The metabolism of drugs may occur in any tissue in the body.

A) Serum concentration-time curve following oral administration of hypothetical drugs. (From Koch-Weser, 1974a. Reprinted by permission from 36 10 Figure 5. 5 to 2 times the maintenance dose), the steady-state serum concentration is achieved more rapidly. tm, the half-life of the drug in the body; D, dose. (From Greenblatt and Koch-Weser, 1975b. Reprinted by permission from The New England Journal of Medicine 293:967) (a) -dose "(b) ^ r% r. 5 x t\nP tmP , 1 , 1 1 j ad ing 5 - 2Z) K f\ (\ /\ r [(dKl \ i \J \J r 1.

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