By Elias J. Corey, Laszlo Kurti

Written via world-renowned and best-selling specialists, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis bargains an authoritative and complete evaluate of the field’s growth; the procedures and instruments for key formations; destiny improvement for complicated, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and necessary examples of multi-step syntheses. using a color-coded scheme to demonstrate chemical changes, Enantioselective Chemical Synthesis presents transparent clarification and suggestions via very important asymmetrical syntheses and perception into the subsequent steps for the sphere. Researchers, execs, and lecturers will make the most of this useful, thorough, and specific source.

  • In half I, the authors current essentially, comprehensively and concisely the main helpful enantioselective methods to be had to man made chemists.
  • Part II offers an in depth dialogue of the main logical how you can practice those new enantioselective how to the making plans of syntheses of stereochemically complicated molecules. This hitherto missed quarter is vital for the development of enantioselective synthesis to a extra rational and strong point.
  • Part III describes intimately many response sequences which were used effectively for the development of a wide selection of complicated objective molecules
  • Clearly explains stereochemical synthesis in conception and practice
  • Provides a handy gizmo field for scientists wishing to appreciate and practice chiral chemical synthesis
  • Describes nearly 50 genuine existence examples of uneven synthesis in perform and examines how the chiral facilities have been brought at key artificial stages

Show description

Read Online or Download Enantioselective Chemical Synthesis. Methods, Logic, and Practice PDF

Similar allied health professions books

Read e-book online Dry Eyes - A Medical Dictionary, Bibliography, and Annotated PDF

This can be a 3-in-1 reference publication. It offers a whole scientific dictionary overlaying countless numbers of phrases and expressions when it comes to dry eyes. It additionally offers wide lists of bibliographic citations. eventually, it presents details to clients on find out how to replace their wisdom utilizing quite a few web assets.

Download PDF by Jane Clifford O'Brien PhD OTR/L: Introduction to Occupational Therapy

A whole assessment of the career and the perform of occupational remedy, creation to Occupational remedy, 4th variation prepares you for the jobs, tasks, and relationships of the OT practitioner. This variation contains the newest revisions of the Occupational remedy perform Framework, which defines the OT technique and parts of outrage.

Read e-book online Neuro-Otology PDF

Neuro-Otology: a quantity within the instruction manual of scientific Neurology series, provides a entire translational reference at the issues of the peripheral and valuable vestibular process. the amount is aimed toward serving medical neurologists who desire to comprehend the most up-tp-date verified details regarding dizziness and disequilibrium from a medical, but scholarly, point of view.

Extra info for Enantioselective Chemical Synthesis. Methods, Logic, and Practice

Example text

J. Org. Chem. 2008, 73, 6928-6931. 37 COREY & KÜRTI: ENANTIOSELECTIVE CHEMICAL SYNTHESIS Katsuki-Sharpless Epoxidation In 1980, T. B. 1 Later, they reported that the inclusion of 4 Å molecular sieves allows the use of substoichiomeric amounts of Ti(Oi-Pr)4 and tartrate ester when dry t-BuOOH is used. This process (Katsuki-Sharpless epoxidation) is now one of the most widely used catalytic 2 asymmetric oxidations in organic synthesis. The 2,3-epoxy alcohols produced by it are valuable chiral building blocks and have been used extensively in the preparation of pharmaceutical intermediates and in the synthesis of many 3 complex natural products.

J. & Rettig, S. J. Catalytic asymmetric hydrogenation of imines. Use of rhodium(I)/phosphine complexes and characterization of rhodium(I)/imine complexes. Inorg. Chem. 1991, 30, 5002-5008. Willoughby, C. A. & Buchwald, S. L. Catalytic Asymmetric Hydrogenation of Imines with a Chiral Titanocene Catalyst: Scope and Limitations. J. Am. Chem. Soc. 1994, 116, 8952-8965. , Andersson, P. G. & Somfai, P. Asymmetric reduction of azirines; a new route to chiral aziridines. Chem. Commun. (Cambridge, U. ) 2002, 1752-1753.

Chem. Rev. 2006, 106, 2126-2208; (g) Hussain, M. M. & Walsh, P. J. Tandem Reactions for Streamlining Synthesis: Enantioand Diastereoselective One-Pot Generation of Functionalized Epoxy Alcohols. Acc. Chem. Res. 2008, 41, 883-893. (a) Behrens, C. H. & Sharpless, K. B. New transformations of 2,3epoxy alcohols and related derivatives. Easy routes to homochiral substances. Aldrichimica Acta 1983, 16, 67-80; (b) Sharpless, K. , Behrens, C. , Lee, A. W. , Martin, V. , Viti, S. , Walker, F. J. & Woodard, S.

Download PDF sample

Rated 4.26 of 5 – based on 31 votes