By Andreas D. Katsambas, Torello M. Lotti, Clio Dessinioti, Angelo Massimiliano D'Erme
This consultant to dermatological remedies offers concise but accomplished, up to date overviews of remedy guidance and pearls for a plethora of epidermis ailments. it really is divided into 3 major sections that handle the various diversified epidermis ailments, the medication on hand for dermatological remedies, and many of the tools utilized in dermatology, together with fillers, botulinum toxin, lasers, dermoscopy, cryosurgery, and electrosurgery. every one epidermis disease-focused bankruptcy describes present remedies whereas additionally delivering a quick synopsis of etiology and medical presentation. remedy symptoms and contraindications, modes of motion, and dosages are sincerely pointed out. This 3rd variation of the ecu instruction manual of Dermatological remedies has been broadly revised to mirror the advances of the previous decade, together with biologic brokers for psoriasis, extensively utilized as promising off-label remedies in different pores and skin illnesses, distinct brokers for malignant cancer and basal mobile carcinoma, and new remedy modalities for rosacea, pimples, atopic dermatitis, and urticaria, to call yet a number of. The winning easy-to-use layout is retained during this re-creation, that's enriched with medical images that would make studying a satisfying in addition to a studying experience.
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Additional info for European Handbook of Dermatological Treatments
D. Katsambas et al. 1007/978-3-662-45139-7_1, © Springer-Verlag Berlin Heidelberg 2015 3 4 Deﬁnition and Epidemiology Acne vulgaris (acne) is the most common skin disorder, affecting more than 80 % of adolescents, although it may present at any age. It has been deﬁned as a chronic inﬂammatory dermatosis characterized by comedones and inﬂammatory lesions, including papules, pustules, and nodules, on sebum-rich body areas such as the face and trunk. It may be associated with a severe psychological and social impairment, as it may result in dysmorphia and permanent scarring, with a risk of low self-esteem and depression.
Hormonal therapy should be individualized for female acne patients. 1 Acne Other Treatment Options for Acne Other therapeutic options that have been used for acne treatment include the extraction of closed and open comedones, laser, and light sources, while chemical peels and lasers may be used for acne scarring. Laser and light therapies, including blue or red light, intense pulsed light (IPL), and pulsed-dye laser (PDL), have been used for acne. It is known that P. acnes produces porphyrins, particularly coproporphyrin III.
The enzymes involved in cutaneous androgen metabolism, such as 5α-reductase type 1, steroid sulfatase, and 3-β hydroxysteroid dehydrogenase, may represent attractive targets for pharmacologic inhibition in acne treatment. Blocking the Activation of Toll-Like Receptors (TLRs) P. acnes has been shown to induce an increased expression of TLR-2, TLR-4, and matrix metalloproteinase-9 (MMP-9) by human keratinocytes and to stimulate keratinocyte proliferation. Blocking the activation of TLRs could therefore represent an attractive therapeutic target.