By Brian F. Hoffman (auth.), Mauricio B. Rosenbaum, Marcelo V. Elizari (eds.)

The objective of this publication is to supply an built-in evaluation of a few exciting difficulties of cardiac electrophysiology. themes were chosen that surround often elements that have been a question of outrage and curiosity in our division over the last few years. We asked from the authors not just that they supply information regarding their very own investiga­ tions, but additionally that they combine their effects with these released through oth­ ers. moreover, we prompt them to be speculative of their interpretations with the intention to inspire exploration of similar parts of research. To this finish, the authors have awarded their ,contributions in adequate element in order that the knowledge won't simply teach the reader but additionally motivate and chal­ lenge him. it really is in the course of the thought of overall integration -from in vitro to in vivo, from animal to guy, from the natural scientist to the clinician -that we are hoping to develop our knowing of cardiac electrophysiology. The ebook brings jointly clinical paintings within which very important advances were made within the seventies, and within which much more titanic seasoned­ gress could be made within the current decade. The chapters were written by way of investigators who're specialists within the proper clinical box. No try at summarizing has been made as this would possibly not seldom result in oversimplification, a danger that we don't dare take. The desk of contents and checklist of participants are, during this regard, self-explanatory.

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This has been found to be the case and the time constant is given by the product Rm x Cm. II. ELECTROTONUS IN CARDIAC TISSUES A. Purkinje fibers The role of electrotonus in the heart is particularly important. It will be apparent later on that the functional geometry of the cardiac 'syncytium' and the peculiar changes in impedance occurring during activity are responsible for marked interactions between passive and active properties of heart tissues. This is not so clearly the case in other excitable tissues (nerve and skeletal muscle).

This suggested that certain AP's term inate after the end of the T but do not generate deflections, because they end simultaneously and undergo cancellation [14] . Figure 3 shows that in our study in dogs we found no evidence in support of such' silent repolarization' on the ventricular surface, since all MAP's terminated during the inscription ofT wave. The same results were obtained by us in rabbit and man (9, 15). CLASSIFI CATION OF T WAVE ABNORMALITIES Primary and secondary T wave abnormalities The concept of YO allows one to define the primary and the secondary T wave abnormalities according to their independence of or dependence on changes in the QRS complex [16].

Electrotonic decay with distance in an 'infinitely' long cable-like fiber. Ordinates: transmembrane potential; abscissae: distance in terms of the space constant A.. For explanation, see text. if the fiber contains several space constants it can be considered, for practical purposes, as infinite in length. The values rm and ri vary from preparation to preparation since the radius of the fibers is not constant. Accordingly, it is necessary to standardize the values obtained for r m and ri, using instead the specific resistances of 1 cm 2 of membrane Rm and 1 cm 3 of endoplasm R i .

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