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35 36 Murray Korc EGF AND THE EXOCRINE PANCREAS A number of observations indicate that EGF participates in the regulation of pancreatic exocrine function. The pancreatic acinar cell has specific high-affinity EGF receptors (28,29), and EGF is necessary for the maintenance of pancreatic acinar cells in serum-free culture medium (6,30). EGF enhances pancreatic protein synthesis at concentrations as low as 42 pM (31), and potentiates CCK-mediated amylase release in cultured acini (29). EGF does not stimulate rat pancreatic acinar cell proliferation in vitro, either in the presence of collagen (32) or in the absence of serum (30,31).

Epidermal growth factor. Ann Rev Biochem 1979;48:193-216. Korc M, Magun BE. Recycling of epidermal growth factor in a human pancreatic carcinoma cell line. Proc Natl Acad Sei USA 1985;82:6172-5. Korc M, Sinman JE. Attenuated processing of epidermal growth factor in the face of transforming growth factor-a. J Cell Biochem 1989;264:14490-9. 4 Regulation of Intracellular Calcium Release and Calcium Uptake by Inositol 1,4,5-trisphosphate in Exocrine Glands Irene Schulz, Frank Thevenod and Martine Dehlinger-Kremer Max-Planck-lnsltut fur Biophysik Kennedyallee 70 6000 Frankfurt a m Main 70 Federal Republic of Germany The intracellular messenger for hormone-induced calcium release is inositol 1,4,5-trisphosphate (IP 3 ), a product of the receptor-mediated breakdown of plasma membrane phosphatidylinositol 4,5-bisphosphate (1,2).

However, to date there are no reports that EGF inhibits the growth of any human pancreatic cancer cell lines. Although EGF receptor overexpression is associated with structural or numerical alterations of chromosome 7 in some of these cell lines, none of these cells demonstrate a measurable increase in the number of copies of the gene coding for the receptor (43). Nonetheless, these cells exhibit an increase in the levels of mRNA coding for the receptor (43). The mechanism underlying this increase in EGF receptor protein and mRNA is not known.

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