By Masayasu Kojima and Kenji Kangawa (Eds.)

This new quantity of Methods in Enzymology maintains the legacy of this premiere serial by way of containing caliber chapters authored by way of leaders within the box. The volume covers ghrelin, and has chapters on such themes as orphan gpcrs and strategies for settling on their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice.

  • Contains caliber chapters authored through leaders within the box
  • Has chapters on such subject matters as orphan gpcrs and techniques for settling on their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice

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Example text

Thus, the GH response of GHRP-6 but not GHRH was acutely downregulated at the pituitary level by continuous but not by hourly, intermittent GHRH or GHRP-6 administration. Also, the in vivo assay of McCormick revealed that the slopes of the dose–response curves to intermittent hourly GHRP-6 versus GHRH were very different. Thus results of these different types of assays supported the conclusion that functionally GHRP-6 was not a GHRH mimic but rather supported the activity of a new hormone and new receptor.

MICHAEL CONN VOLUME 357. Cytochrome P450, Part C Edited by ERIC F. JOHNSON AND MICHAEL R. WATERMAN VOLUME 358. Bacterial Pathogenesis (Part C: Identification, Regulation, and Function of Virulence Factors) Edited by VIRGINIA L. CLARK AND PATRIK M. BAVOIL VOLUME 359. Nitric Oxide (Part D) Edited by ENRIQUE CADENAS AND LESTER PACKER VOLUME 360. Biophotonics (Part A) Edited by GERARD MARRIOTT AND IAN PARKER VOLUME 361. Biophotonics (Part B) Edited by GERARD MARRIOTT AND IAN PARKER VOLUME 362. Recognition of Carbohydrates in Biological Systems (Part A) Edited by YUAN C.

MICHAEL CONN Methods in Enzymology VOLUME 387. Liposomes (Part D) Edited by NEJAT DU¨ZGU¨NES¸ VOLUME 388. Protein Engineering Edited by DAN E. ROBERTSON AND JOSEPH P. NOEL VOLUME 389. Regulators of G-Protein Signaling (Part A) Edited by DAVID P. SIDEROVSKI VOLUME 390. Regulators of G-Protein Signaling (Part B) Edited by DAVID P. SIDEROVSKI VOLUME 391. Liposomes (Part E) Edited by NEJAT DU¨ZGU¨NES¸ VOLUME 392. RNA Interference Edited by ENGELKE ROSSI VOLUME 393. Circadian Rhythms Edited by MICHAEL W.

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