By S. Rakoff-Nahoum, R. Medzhitov (auth.), Tasuku Honjo MD, Ph.D., Fritz Melchers (eds.)
The gut is colonized by means of a powerful group of commensals, that has profound results at the immune funtions. the connection among intestine microbiota and the immune procedure is one in all reciprocity: commensals have very important contribution in nutrient processing and schooling of the immune process and conversely, the immune process, quite gut-associated lymphoid tissues performs a key function in shaping the repertoire of intestine microbiota.
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Extra resources for Gut-Associated Lymphoid Tissues
2000). Studies in mice with mutations in individual Rel/NF-κB family members have demonstrated that both NF-κB1 and NF-κB2 signaling pathways are critical for PP and LN organogenesis and formation of lymphoid tissue architecture, although NF-κB1-deﬁcient mice show a milder phenotype. RelB (NF-κB2-subunit)-deﬁcient mice lack all LNs (Weih et al. 1995). PPs are barely detectable in RelB−/− , NF-κB2−/− , and IKKα−/− mice, whereas in NF-κB1−/− mice, LNs are normal, although PPs appear to be reduced in size and number (Matsushima et al.
Meier Fig. 1A–D Organized GALT in adult mice. PPs in the small intestine (A) and hematoxylin-eosin (HE) staining of frozen sections of PPs in small intestine (B). ILF (C) and CP (D) localized in the small intestine can bind to MAdCAM-1 and allow migration to the GALT. The subepithelial CD11c+ CD11b+ CD8α− DCs are localized in close contact to M cells to uptake and process Ags (Iwasaki and Kelsall 2000). Moreover, the intestinal epithelium contains intraepithelial CD11c+ CD11b− CD8α− DCs, which can uptake luminal Ags through direct sampling from the lumen (Niess et al.
D. Meier is supported by the Wehrenfels Foundation. References Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299:247–251 Adachi S, Yoshida H, Honda K, Maki K, Saijo K, Ikuta K, Saito T, Nishikawa S (1998) Essential role of IL-7 receptor αin the formation of Peyer’s patch anlage.