By Thomas R. Browne, Gregory L. Holmes
Thoroughly up-to-date for its Fourth version, this best-selling pocket reference is a pragmatic point-of-care consultant to the prognosis and administration of epilepsy. In an easy-to-use define structure, the booklet offers entire, clinically targeted info on seizure category, epilepsies with diverse a while of onset, situation-related epilepsy, analysis and differential analysis, and all to be had drugs, together with dosages, negative effects, and drug interactions.
This edition's up to date insurance of drug treatment contains present American Academy of Neurology directions, new medications, newly authorized symptoms, new details on pharmacokinetics, and result of six registries of antiepileptic medicinal drugs in being pregnant. New info at the genetics and molecular biology of numerous epilepsy syndromes is usually included.
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Extra resources for Handbook of Epilepsy
The treatment of epilepsy: principles and practice. Philadelphia: Lippincott Williams & Wilkins, 2001:115–130. 27. Wyllie E, ed. The treatment of epilepsy: principles and practice. 3rd ed. Philadelphia: Williams & Wilkins, 2001. 28. Kandel ER, Schwartz JH, Jessell TM. Principles of neural science. 4th ed. New York: McGraw-Hill, 2000. qxd 1/16/08 11:57 AM Page 24 2 Types of Seizures An epileptic seizure is classified as a single event based on clinical and electroencephalographic (EEG) information.
Transient paralytic phenomena (Todd paralysis) are a common postictal manifestation of an excitatory clonic seizure, especially if it is severe or repeated. With somatic inhibitory seizures, sensory loss or dysesthesia and weakness occur. Versive seizures consist of conjugate eye movements and turning of the head to the same side. Parietal and temporal lobe seizures may produce homolateral or contralateral versive movements, and occipital seizures usually produce contralateral versive movements.
The lack of an efficient time-locked inhibition, the delayed maturation of postsynaptic GABAB-mediated currents, and the high input resistance of small compact neurons will facilitate the generation of action potentials and synchronized activities. At more developed stages, in rodents during the second postnatal week, enhanced excitation may play an additional role in the propensity of the immature brain for seizures. With maturation, axonal collaterals and attendant synapses regress. REFERENCES 1.