By Ricardo Munoz, Eduardo M. da Cruz, Carol G. Vetterly, David S. Cooper, Donald Berry

This guide of substances utilized in pediatric cardiac care will fulfill the necessity for a fast reference resource of universal drug remedy. There are not any significant texts on hand within the box of pediatric cardiology that solely supply healing drug info. numerous assets can be found that current drug info for cardiology, yet those position no emphasis on pediatric care and are written for basic cardiac experts.

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Dopamine Indication Dopamine is an adrenergic agonist agent (sympathomimetic) with moderate α1-, α2- and β1-receptor stimulator effects and a mild β2 effect. It also acts directly on dopaminergic (DA1 and DA2) receptors. Therefore, dopamine increases cardiac contractility and output and improves blood pressure27–29, 33. When used after adequate fluid replacement, dopamine increases urine output. Its effects are dose dependant. In some postoperative cardiac pathologies, such as Fallot’s tetralogy or in patients undergoing a Stage 1 Norwood procedure, high doses of dopamine may exert negative effects35.

4% were classified as relative contraindications for use and none resulted in adverse events documented in patient records. 5 million persons have been exposed to a drug-drug combination judged to be clinically important, with more women than men and more older individuals than younger individuals exposed. 11 Data in pediatric populations are generally lacking, although Novak et al. 12 Implications of CYP-450 Drug-Drug Interactions of Cardiovascular Drugs The CYP-450 system may have significant effects on cardiovascular drug therapy.

9 Substrates for this isoenzyme system include omeprazole, S-warfarin, propranolol, topiramate, and diazepam. Examples of drugs that may inhibit this system include fluconazole and potentially other azole antifungals, omeprazole, sertraline, fluoxetine, and isoniazid. Inducing substances include phenytoin, phenobarbital, and carbamazepine, as well as rifampin. A fourth isoenzyme pathway responsible for metabolism of approximately 5% of drugs is the CYP1A2 system, with important substrates, including theophylline, R-warfarin, and caffeine, and notable inhibitors, including azole antifungals; macrolides, including erythromycin; fluvoxamine; paroxetine; and isoniazid.

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