Chapter 1 Chromosome Maps (pages 1–39): T. P. pace and H. Zhao
Chapter 2 Statistical importance in organic series comparability (pages 40–66): W. R. Pearson and T. C. Wood
Chapter three Bayesian equipment in organic series research (pages 67–96): Jun S. Liu and T. Logvinenko
Chapter four Statistical ways in Eukaryotic Gene Prediction (pages 97–159): V. Solovyev
Chapter five Comparative Genomics (pages 160–199): J. Dicks and G. Savva
Chapter 6 research of Microarray Gene Expression facts (pages 201–230): W. Huber, A. von Heydebreck and M. Vingron
Chapter 7 Statistical Inference for Microarray experiences (pages 231–266): S. B. kilos, C. Cheng and A. Onar
Chapter eight Bayesian equipment for Microarray information (pages 267–295): A. Lewin and S. Richardson
Chapter nine Inferring Causal institutions among Genes and affliction through the Mapping of Expression Quantitative Trait Loci (pages 296–326): S. okay. Sieberts and E. E. Schadt
Chapter 10 Protein constitution Prediction (pages 327–346): D. P. Klose and W. R. Taylor
Chapter eleven Statistical suggestions in Metabolic Profiling (pages 347–373): M. De Iorio, T. M. D. Ebbels and D. A. Stephens
Chapter 12 Adaptive Molecular Evolution (pages 375–406): Z. Yang
Chapter thirteen Genome Evolution (pages 407–438): J. F. Y. Brookfield
Chapter 14 Probabilistic versions for the learn of Protein Evolution (pages 439–459): J. L. Thorne and N. Goldman
Chapter 15 software of the chance functionality in Phylogenetic research (pages 460–488): J. P. Huelsenbeck and J. P. Bollback
Chapter sixteen Phylogenetics: Parsimony, Networks, and Distance equipment (pages 489–532): D. Penny, M. D. Hendy and B. R. Holland
Chapter 17 Evolutionary Quantitative Genetics (pages 533–586): B. Walsh
Chapter 18 Quantitative Trait Loci in Inbred traces (pages 587–622): R. C. Jansen
Chapter 19 Mapping Quantitative Trait Loci in Outbred Pedigrees (pages 623–677): I. Hoschele
Chapter 20 Inferences from combined versions in Quantitative Genetics (pages 678–717): D. Gianola
Chapter 21 Marker?Assisted choice and Introgression (pages 718–751): L. Moreau, F. health center and J. Whittaker
Chapter 22 Mathematical types in inhabitants Genetics (pages 753–780): C. Neuhauser
Chapter 23 Inference, Simulation and Enumeration of Genealogies (pages 781–807): C. Cannings and A. Thomas
Chapter 24 Graphical versions in Genetics (pages 808–842): S. L. Lauritzen and N. A. Sheehan
Chapter 25 Coalescent conception (pages 843–877): M. Nordborg
Chapter 26 Inference lower than the Coalescent (pages 878–908): M. Stephens
Chapter 27 Linkage Disequilibrium, Recombination and choice (pages 909–944): G. McVean
Chapter 28 Inferences from Spatial inhabitants Genetics (pages 945–979): F. Rousset
Chapter 29 research of inhabitants Subdivision (pages 980–1020): L. Excoffier
Chapter 30 Conservation Genetics (pages 1021–1066): M. A. Beaumont
Chapter 31 Human Genetic variety and its heritage (pages 1067–1108): G. Barbujani and L. Chikhi
Chapter 32 Epidemiology and Genetic Epidemiology (pages 1109–1140): P. R. Burton, J. M. Bowden and M. D. Tobin
Chapter 33 Linkage research (pages 1141–1167): E. A. Thompson
Chapter 34 Non?Parametric Linkage (pages 1168–1189): P. Holmans
Chapter 35 inhabitants Admixture and Stratification in Genetic Epidemiology (pages 1190–1215): P. M. McKeigue
Chapter 36 inhabitants organization (pages 1216–1237): D. Clayton
Chapter 37 complete Genome organization (pages 1238–1263): A. P. Morris and L. R. Cardon
Chapter 38 Family?Based organization (pages 1264–1285): F. Dudbridge
Chapter 39 melanoma Genetics (pages 1286–1300): M. D. Teare
Chapter forty Epigenetics (pages 1301–1321): okay. D. Siegmund and S. Lin
Chapter forty-one Ethics matters in Statistical Genetics (pages 1323–1345): R. E. Ashcroft
Chapter forty two assurance (pages 1346–1367): A. S. Macdonald
Chapter forty three Forensics (pages 1368–1392): B. S. Weir
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Additional resources for Handbook of Statistical Genetics, Third Edition
Open Reading Frame (ORF): a long sequence of DNA with an initiation codon at the 5 -end and no termination codon except for one at the 3 -end. PCR (polymerase chain reaction): a laboratory process by which a specific, short, DNA sequence is amplified many times. Pedigree: a diagram showing the relationship of each family member and the heredity of a particular trait through several generations of a family. Penetrance: the probability that a particular phenotype is observed in individuals with a given genotype.
Jude Children’s Research Hospital Memphis, TN USA xxxii CONTRIBUTORS S. P. Speed Department of Statistics University of California at Berkeley Berkeley, CA USA F. Rousset Laboratoire G´en´etique et Environnement ´ Institut des Sciences de l’Evolution Montpellier, France and G. E. A. K. D. Siegmund Department of Preventive Medicine Keck School of Medicine University of Southern California Los Angeles, CA USA V. A. Stephens Department of Mathematics and Statistics McGill University Montreal, Canada M.
Guanine (G): purine base that forms a pair with cytosine in DNA. Haemoglobin: is the red oxygen-carrying pigment of the blood, made up of two pairs of polypeptide chains called globins (2α and 2β subunits). Haploid: has a single version of each chromosome. Haplotype: the alleles at different loci on a chromosome. An individual’s two haplotypes imply the genotype; the converse is not true, but in the presence of strong linkage disequilibrium haplotypes may be inferred from genotype with few errors.