By M. Agulnik

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1988), analysing the results of radiotherapy in hypopharyngeal cancer with special attention paid to the nodal control, pointed out the role of postoperative radiotherapy in obtaining an effective nodal control for patients with clinically positive nodes. The use of postoperative radiotherapy following neck lymph node dissection is recommended for patients with N2 and N3 disease. , 2000). Postoperative radiotherapy in patients with resectable locally and/or regionally advanced hypopharyngeal cancer should be prescribed to the entire operative bed and draining nodes.

2004). Both trials evaluated the role of concomitant cisplatin given every 3 weeks (100 mg/m2 on days 1, 22, 43) during radiotherapy course (Table 2). Retrospective analysis of data from both trials, revealed that extracapsular extension of nodal disease and/or microscopically involved surgical margins were the only risk factors for which the impact of concurrent chemoradiotherapy was significant in both trials (Bernier & Cooper, 2005). In 2004, National Cancer Institute (NCI) level I evidence for recommendation was established, because both studies demonstrated that adjuvant concurrent chemoradiotherapy was more efficacious with respect to radiotherapy alone in terms of locoregional control and disease-free survival (Bernier & Cooper, 2005).

In a study of hyperfractionation, Jeremic et al. , 2000) reported a significant improvement in 3-year locoregional control, overall survival and distant-metastases-free survival with hyperfractionated radiotherapy and concurrent low-dose daily cisplatin as compared with hyperfractionation alone (Table 3). The reported frequency of acute mucositis and late complications were similar in both arms. The improvement of therapeutic index of hyperfractionated radiotherapy by concomitant cisplatin has been also confirmed in the randomised trial conducted by Huguenin et al.

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