By Mark A. Herbert, Derek W. Hood, E. Richard Moxon

In HaemophilusiInfluenzae Protocols, best learn scientists and infectious affliction experts element in a quite simply reproducible layout the main molecular and immunological concepts for exploring the pathogenicity of H. influenzae. defined with step-by-instructions to make sure powerful and profitable experimental effects, the innovations hide plasmid research, proteomics, genomics, DNA array expertise, gene expression, mutagenesis (transposon and nontransposon), and structural research. those tools remove darkness from how the bacterium motives illness, in addition to how top to enhance novel vaccines and antibiotics opposed to the organism.

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Additional resources for Hemophilus Influenzae Protocols (Methods in Molecular Medicine)

Sample text

58. Miyamoto, N. and Bakaletz, L. O. (1996) Selective adherence of non-typeable Haemophilus influenzae (NTHi) to mucus or epithelial cells in the chinchilla Eustachian tube and middle ear. Microb Pathog. 21, 343–356. 59. Denny, F. W. (1974) Effect of a toxin produced by Haemophilus influenzae on ciliated respiratory epithelium. J. Infect. Dis. 129, 93–100. 60. Johnson, A. P. and Inzana, T. J. (1986) Loss of ciliary activity in organ cultures of rat trachea treated with lipo-oligosaccharide from Haemophilus influenzae.

Thereby the antibody molecules are left as intact Fab (monomeric) fragments devoid of the Fc portion, which is particularly responsible for the protective properties of this immune factor (80). Upon cleavage, the 50-kDa C-terminal domain of the IgAl protease remains in the bacterial outer membrane, while the proteolytically active N terminus is secreted. For H. influenzae, at least two classes of IgAl proteases have been described based on cleavage at either a prolyl-seryl (designated type 1) or four amino acids away at a prolylthreoryl bond (type 2) (81–83).

The availability of the whole genome sequence of H. influenzae (strain Rd) permitted the identification of another tetranucleotide repeat-containing LPS gene along with up to 30 more non-repeat-containing candidate LPS genes. Importantly, the high-frequency on–off switching of phase-variable loci permits the generation of a plethora of LIPS glycoforms. The most appropriate form may then be selected at each stage of pathogenesis. 5. Capsule Polysaccharide capsules are considered important determinants of pathogenicity in several species of bacteria (115).

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