By Yie Chien

A complete therapy of the technology, know-how, and legislation of rate-controlled management of healing brokers, with insurance of the fundamental techniques, basic rules, biomedical rationales, and capability functions. This revised and up to date version (first in 1982) accommodates

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1985 Internatioinal Pharmaceutical R&D Symposium on Advances in Transdermal Controlled Drug Administration for Systemic Medication, Rutgers University, College of Pharmacy, Piscataway, New Jersey, June 20 and 2 1 , 1985. Proceedings published in Transdermal Controlled Systemic Medications (Yie W. ), Dekker, New York (1987). Y. W. Chien; Rate-control drug delivery systems: Controlled release vs. sustained release. Medical Progress Through Technology, 15:21-46 (1989). Concepts and System 5. 6. 7.

Medical Progress Through Technology, 15:21-46 (1989). Concepts and System 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. J. Segal; The development of Norplant implants. Studies in Family Planning, 14:161 (1983). S. ; A Five-year clinical trial of levonorgestrel silastic implants (Norplant). Contraception, 25:447 (1982). E. ; Plasma Levels of d-norgestrel after oral administration. Contraception, 23:197 (1981). H. B. ; Plasma levels of levonorgestrel in women during long-term use of Norplant.

The release of Valium molecules is then controlled by matrix diffusion through this gel barrier; the tablet remains buoyant in the stomach as a result of the density difference between the gastric fluid id > 1) and the gelling tablet (d < 1) (2,39). In addition to the hydrophilic polymers, lipophilic polymers, such as silicone elastomer, can also be modified to have swelling properties (56-60). 2 Plasma Insulin Cone. 2 sz I Infection • 1** I I I 0 48 | l > —i 96 *—•— — i - — i — i — i 98 Time (hr) 102 106 0 48 96 98 102 106 Time ( h r ) Figure 24 Application of the transdermal periodic iontotherapeutic system (TPIS), an iontophoresis-activated drug delivery system, for the transdermal controlled delivery of insulin to diabetic rabbits and the reduction in blood glucose level from the hyperglycemic state compared to conventional subcutaneous administration.

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