By John B. West

This is the 1st pulmonary medication monograph to mix body structure and pathophysiology. content material is formatted round 9 case studies--two pertaining to basic topics and 7 offering ailments reminiscent of persistent obstructive pulmonary ailment, bronchial asthma, diffuse interstitial lung pulmonary fibrosis, pulmonary embolism, pulmonary edema, coal employees' pneumoconiosis, and acute respiration failure. This concise textual content is ideal for built-in classes and gives rapid medical functions to uncomplicated technology concepts.

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As a consequence, ai rway closure occurs in this region, and no gas enters with small inspirations. The alveoli at the lung base still conta in some a i r. 41 Chronic Obstructive Pulmonary Disease that it represents the situation at residual volume (that is, after a maximal expiration; see Fig. 3-6). Now the intrapleural pressures are less negative, because the lung is not so well expanded and the elastic recoil forces are smaller. However, the differences between the apex and base are still present because of the weight of the lung.

For exam­ ple, an anesthetized patient will frequently stop · · 0 0 20 20 : 30 30 40 40 50 50 Alveolar Pco2 (mm Hg) FIGURE 2-8. Ventilatory responses to C0 2 . Each curve of total ventilation against alveolar Pco2 is for a different alveolar Po2. In this study, no d ifference was found between a n alveolar Po2 of 1 1 0 mm H g a n d o n e of 1 69 m m Hg, although some investiga­ tors have found that the slope of the line is slightly less at the higher Po2. breathing for a minute or so if he or she is first overventilated by the anesthesiologist.

T¥1it. 1ifJ 29 ( For answers, see p. 1 42) For each question, choose the one best answer. 1 . The Po2 of moist inspired air (in mm 5. 5. Hg) at an altitude o f 6500 m (barometric pressure 3 47 mm Hg) is: A. 5 3 B. 63 c. 73 D. 8 3 E. 93 2 . A healthy medical student breathing air voluntarily hyperventilates and doubles his alveolar ventilation for several minutes. 8 before and after the hyperventilation, approximately how much does his alveolar Po2 rise in mm Hg? A. 20 B. 2 5 c. 30 D. 3 5 E . 40 3 .

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