By Berger M.S., Prados M.
Explores all the such a lot difficult neurologic cancers that clinicians face
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Extra resources for Textbook of Neuro-Oncology
Such differences would affect the prognostic capability of a classiﬁcation system. The obvious differences in children’s and adults’ brains with respect to lineage and phenotypic differentiation are consistent with the existence of different cellular targets for neoplastic transformation. On the simplest level, this distinction is reﬂected by the different histogenetic potential and molecular biology of the most common malignant tumors, the medulloblastoma25 and glioblastoma,109 in children’s and adults’ brains, respectively.
TUMORS ARISING FROM NEUROEPITHELIAL CELLS Astrocytic Tumors Diffuse Astrocytomas The current WHO classiﬁcation of CNS tumors57,58 recognizes two different categories of astrocytic tumors. The ﬁrst category, the diffuse astrocytomas, is so designated because these tumors invade the brain or spinal cord tissue by diffuse cellular inﬁltration at regional margins and cellular dispersion to distant sites. Aside from the capacity to diffusely invade the adjacent neuropil or white matter and to spread remotely, a diffuse-type astrocytoma has a signiﬁcant potential to develop progressively more malignant biologic behavior with time.
Miller DC, Lang FF, Epstein FJ: Central nervous system gangliogliomas. Part 1: Pathology. J Neurosurg 79:859–866, 1993. Porta-Etessam J, Berbel A, Martinez-Salio A, et al: Gliomatosis cerebri. MRI, SPECT and the study of pathology. Rev Neurol 29:287–288, 1999. Reni M, Ferreri AJ, Garancini MP, Villa E: Therapeutic management of primary central nervous system lymphoma in immunocompetent patients: results of a critical review of the literature. Ann Oncol 8:227–234, 1997. Rippe DJ, Boyko OB, Fuller GN, et al: Gadopentetate-dimeglumine-enhanced MR imaging of gliomatosis cerebri: appearance mimicking leptomeningeal tumor dissemination.